Noncanonical NF- B Signaling Is Limited by Classical NF- B Activity

colorectal cancer and nf-?b signaling pathway

colorectal cancer (crc) is the second leading cause of cancer death. progress has been made in the development of chemotherapy for advanced crc. targeted therapies against vegf or egfr are now commonly used. however, many cases show that tolerance develops to such treatments; therefore, new strategies are required to replace or complement current therapies. nuclear factor-?b (nf-?b) transcripti...

Signaling to NF - B

-Arrestin inhibits NF- B activity by means of its interaction with the NF- B inhibitor I B

In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, -arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NFB, I B , as a binding partner of -arrestin 1. Both -arrestin 1 and 2 interact with I B in transfected cells as assessed by ...

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-κB pathway and promotes lymphomagenesis

CD40, a member of the tumor necrosis factor (TNF) receptor family, plays an essential role in T cell-dependent immune responses. Because CD40 is widely expressed on the surface of tumor cells in various B cell malignancies, deregulated CD40 signaling has been suggested to contribute to lymphomagenesis. In this study, we show that B cell-specific expression of a constitutively active CD40 recept...

Negative Regulation of NF- B Signaling by PIAS1†

Negative Regulation of NFB Signaling by PIAS1† Bin Liu, Randy Yang, Kelly A. Wong, Crescent Getman, Natalie Stein, Michael A. Teitell, Genhong Cheng, Hong Wu, and Ke Shuai* Division of Hematology-Oncology, Department of Medicine, Department of Biological Chemistry, Molecular Biology Institute, Department of Molecular and Medical Pharmacology, Department of Pathology and Pediatrics, Department o...